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Radiologic changes in the aging nasal cavity

Volume: - Issue:

Firstpage: 0 - Lastpage: 0

Kimia G. Ganjaei - Zachary M. Soler - Elliott D. Mappus - Mitchell L. Worley - Nicholas R. Rowan - Guilherme J.M. Garcia - Lois J. Matthews - Judy R. Dubno - Mark A. Eckert - Rodney J. Schlosser

BACKGROUND: With an aging population, it is important to understand age-related anatomic changes in the nasal cavity and cribriform plate (CP) that may have clinical implications.
METHODOLOGY: Computed tomography (CT) scans obtained for non-rhinologic conditions were divided into a young cohort (N=35, 18-34 years old) and an older adult cohort (N=32, 80-99 years old). Intranasal airspace volumes and bony anatomy of the CP were manually segmented using OsiriX software. The CP was assessed for mean Hounsfield Units (HU) and percentage of olfactory foramina. Deformation based morphometry (DBM) was then performed on the same cohort and correlated with manual measurements.
RESULTS: Individual nasal cavity volumes increased 17-75% with age. Regression analysis of all scans revealed age to be the predominant variable influencing intranasal volume differences when controlling for sex and head size. Mean HU of the CP negatively correlated with age. No age-related differences in bone stenosis of olfactory foramina were identified. Automated DBM measurements of intranasal volumes, as well as CP and zygoma mean HU correlated with manual measurements.
CONCLUSION: Older subjects have a global increase in intranasal volumes and diffuse bone density loss in the CP. The clinical impact of age-related anatomic changes in the nasal cavity and CP requires further investigation.

Kimia G. Ganjaei - Zachary M. Soler - Elliott D. Mappus - Mitchell L. Worley - Nicholas R. Rowan - Guilherme J.M. Garcia - Lois J. Matthews - Judy R. Dubno - Mark A. Eckert - Rodney J. Schlosser - Radiologic changes in the aging nasal cavity
Rhinology -: 0-0, 0000